Resveratrol: Red Wine Antioxidant

Anti aging Information and Resveratrol

Superoxide dismutase, catalase, glutathione peroxidase, methionine reductase

SOD / CAT, developed in 1983, was the inducer antioxidant enzyme first sale in the United States. This is a unique ingredient of dietary supplements that supposedly to increase the body's antioxidant defenses by increasing superoxide dismutase (SOD as CuMn, aka SOD2), catalase, glutathione peroxidase (GPx), and methionine reductase [1]. The product is manufactured by Biotec Foods, a Agrigenic Food Company division. USPTO registration number 2933330 [1], [Patent 60,864,798]. According to the website of the company, product information has not been reviewed by the Food and Drug Administration, and the product should not be used to cure, prevent or alleviate the disease [2].

Ingredients

SOD / CAT glycine is Max T. durum, Zea mays cabbage, and provides prebiotic oligosaccharides and probiotics bifidobacteria and lactic acid bacteria, cyanocobalamin, methylcobalamin, and organically bound selenium.

Mechanism of action

According to the manufacturer, the preparation does not work directly as an antioxidant, but like other plant-derived phytoestrogens, including resveratrol. [3] [4] The preparation is claimed to trigger a signaling cascade, ultimately activating the genes of a family of antioxidant enzymes for protection, including including superoxide dismutase (SOD), catalase (CAT). [5] [6] [7] organically bound selenium preparation for the promotion of glutathione peroxidase activity separately [8] and its specialized form of vitamin B-12 promotes methionine (synthase) reductase activity [9]. Therefore, the preparation reduces oxidative stress by increasing the capacity of endogenous antioxidant enzymes.

According to the manufacturer, is developed and designed to convert the lower of phytoestrogens phytoestrogens, which are in many conventional foods and supplements, and more powerful, ER-beta high affinity. The manufacturer estimates that a high degree of synchronization and Synergy is required to produce the desired compounds through endogenous. Interaction prebiotics, probiotics, intestinal microflora exists, and the compound daidzein and other polyphenols, antioxidants and phytoestrogens in the preparation is likely converted to S-equol, O-desmethylangolensin and their endogenous analogues. [10] The compound crystallized instead of pulverized into a fine powder, then compressed into tablets. Granulation and coating are important because the key ingredients interaction should take place the small intestine after preparation passes safely through the stomach acid. The compounds and phytoestrogens genistein derivatives act as selective modulators of estrogen receptor site (SERMs) to regulate SOD and catalase expression by acting as signaling molecules. [11] [12] [13]

chemical structures of the most common phytoestrogens in plants (high and medium) compared to estrogens (Bottom) in animals.

Relations with caloric restriction

The exact mechanism of activation of genes, the exact number and identity of the genes activated, and the main purpose of evolution or the origin of these genes remains uncertain. However, a renewed interest and research on life extension through caloric restriction, and fund research on compounds like polyphenols and phytoestrogens, although lacking scientific consensus – suggests that these genes have evolved to extend the life during periods of near starvation [14], and that these genes can be directly activated by food stimuli. However, without a scientific consensus, this theory remains speculative.

Product Development History

The first official investigation into human subjects has been the Smith-Kline in more than sixty-five of the study a small number of people from 1965 to 1978, began in 1989 as a placebo, sponsored by the manufacturer-controlled double-blind trial in Honolulu, Hawaii for Smith-Kline, Accupath. [15]. The results suggest that the beneficial effects, the observations anecdotal evidence of benefits are associated with erythrocyte superoxide dismutase and catalase increase observed after three weeks of supplementation. Participants outside of the control group showed an average increase in erythrocyte superoxide dismutase by 230%. A control group with a placebo consisting of inactivated (castrated) version of the ingredient, have risen much smaller erythrocyte superoxide dismutase and catalase the same after three weeks of supplementation. Catalase activity was measured by the decrease in plasma hydrogen peroxide, comprising measuring the levels of TBARS, erythrocyte superoxide dismutase (SOD), catalase and the levels of before and after administration Supplement 17 healthy adults. The substances are measured oxidative stress markers [16].

5 published studies

5.1 Study of Chernobyl

In 1991, Biotec Foods-Hawaii, Ltd., the predecessor funded a study entitled Agrigenic "Health Effects of protective cells in children and adolescents from Belarus exposed to radiation as a result of the Chernobyl AES. Researchers Gres NA Poliakova major IT and published their findings in a Russian language newspaper. A translation of the study is published on the site Agrigenic. Video of the company's Web promanently includes interviews with senior researchers.

5.2 Life Extension Foundation Studies

In 2005, Life Extension Foundation has conducted several studies independent. In the first open trial, 12 volunteers with a mean age of both sexes took 2000 mg daily produced over two weeks. Promoted serum SOD 30% on average while reducing blood levels of hydrogen peroxide of 47%. This is important because hydrogen peroxide can help to inflammation of arthritis. While immune cells do so at intervals of hydrogen peroxide to kill viruses and bacteria, excess peroxide hydrogen can contribute to inflammation and arthritis. The 12 subjects in this study, whose average age was 58 years, has suffered from arthritis, but began to experience normal decline due to age their levels of SOD. Two weeks of oral supplementation restored the serum and blood levels of SOD to the parameters of the young. In addition, supplementation stimulates the activity of blood catalase, another antioxidant enzyme, 47%. A second pilot (placebo) published by extending life [3] has examined their effects on adults diagnosed with inflammatory diseases like arthritis. This placebo controlled cons, 3-arm study with 30 subjects over test four weeks placebo, probiotics SOD / CAT and probiotics SOD / CAT (placebo). A dramatic response 71% (clinically defined as a reduction significant pain measured by a pain assessment tool validated) in the probiotic group SOD CAT / compared with a 30% response group was not observed probiotics. No differences were observed in the placebo group. Those who suffer the most pain at baseline experienced the greatest benefit of the product for pain relief [4].

6 Other Trade Names

SOD / CAT and dietary supplements represents the following brands: mobile watch, Synovalex, AOX / PLX, Anti-stess Enzymes, Ageless Beauty, Extra Energy Enzymes, SODZyme, Biovet IsoSproutPlex dismutase. In Japan, the supplement is branded as V-Pet.

7 veterinary use

In addition to veterinary medicine, is marketed as AOX / PLX, Biovet dismutase, supporting canine and feline support and was used as a dietary supplement to help reduce inflammation. [17]. Some homeopathic practitioners, veterinarians documented its successful use of the antioxidant enzyme agonists instead of the traditional medicine of steroids, which can have significant side effects .. [3], [four].

Eight competing technologies

inducers of antioxidant enzymes, including SOD / CAT, Protandim, resveratrol and Wolfberry, and other oral forms of SOD, including GliSODin and extracts from bovine liver sold as dietary supplements rather than drugs.

8.1 U.S. Regulation supplements diet

While being served by the U.S. Food Administration Drug and food supplements are regulated by the Dietary Supplements Health and Education Act of 1994DSHEA [5]. DSHEA no rigorous scientific evidence necessary for FDA approval of new drug applications (NDA). Consequently, dietary supplements should limit its commercial speech that promotes efficiency the product to what is called the structure-function claims, which must be communicated in writing to the FDA refused as follows: This information has not been reviewed by the Food and Drug Administration. This product should not be used to cure, prevent or mitigate a disease.

8.2 drug approved: Orgotein: Injection of SOD

An injectable form of superoxide dismutase (orgotein), obtained from beef liver, is an approved drug, and promoted as an anti-aging forscleroderma and effective treatment, radiation induced cystitis, osteoarthritis, inflammation and urinary tract diseases. The Food and Drug Administration (FDA) has classified the parenteral formulation of the agent as an orphan drug used for familial forms of amyotrophic lateral sclerosis (ALS) and (ALF) [18].

Orgotein is the form of CuZn superoxide dismutase, or SOD1, extracellular. Recent medical research indicates that the FALS occurs when the SOD1 gene inexplicably begins to produce proteins misfolded SOD1 ineffective, thus exposing the motor neurons of superoxide free radicals. Other research is needed to understand the underlying causes [19].

Bovine extracts ingested 8.3: ineffective

Several supplements manufacters promote livestock feed extracts as an oral form of SOD, however, the effectiveness of oral intake of extracts of bovine SOD greatly reduced. [20] SOD bovine extracts is rapidly degraded by gastric acid when ingested. It is mainly absorbed after oral administration, although the enteric coating, and confers no pharmacological activity orally. Although many foods (red meat, vegetables) are rich in SOD, SOD is degraded through ingestion, becoming enzymatically inactive.

9 See also

• List of Members Topics
• Free Radical Biology and Medicine
• Superoxide dismutase and catalase
• Antioxidant enzymes
• SERM estrogen receptor beta and S-equol Site
• Caloric restriction Life Extension

10 References

1. ^ [EC 1.18.1.]
2. ^ [1]
3. ^ Robb EL, Page MM, Wiens BE, Stuart JA (March 2008). "Molecular mechanisms of resistance to oxidative stress induced by resveratrol, and specific induction MnSOD progressive. Biochem Biophys Res Commun. 367 (2): 406-12. Doi: 10.1016/j.bbrc.2007.12.138. PMID 18167310.
4. ^ Kops, GJ Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Security, PJ, Huang TT, Bos JL Medem RH, Burgering BM (September 2002). "Forkhead transcription factor FOXO3a protects cells against oxidative stress at rest. "Nature 419 (6904): 316-21. Doi: 10.1038/nature01036. PMID 12,239,572.
5. ^ Coleman, John (2005). "Changes in serum levels of superoxide dismutase and catalase in humans after supplementation of food SODzyme. Life Extension Foundation.
6. ^ Coleman, John (April 2005). "Effects of oral administration SODzyme in pain scores in humans with arthritis." Life Extension Foundation.
7. ^ Rothschild, Peter, et al. al (1988). "Absorption of Oral enzyme therapy enzyme and immune complexes and quota free radicals University diseases .. laboratories Press, Honolulu, Hawaii.
8. ^ U Tinggi (March 2008). "Selenium: its role as an antioxidant for health human. "Environment Health Prev Med 13 (2): 102-8. Doi: 10.1007/s12199-007-0019-4. PMID 19568888.
9. ^ Olteanu H, Banerjee R (September 2001). "The methionine synthase reductase human, soluble P-450-double as reductase flavoprotein, is sufficient to support methionine synthase activation of NADPH. J. Biol. Chem 276 (38): 35558-63. Doi: 10.1074/jbc.M103707200. PMID 11466310.
10. ^ S Raimondi, Roncaglia L, De Lucia M, Amaretti A, Leonardi A, Pagnoni UM, Rossi M (January 2009). "Bioconversion of soy isoflavones daidzin and daidzein by strains Bifidobacterium. Appl. Microbiol. Biotechnol. 81 (5): 943-50. Doi: 10.1007/s00253-008-1719-4. PMID 18820905.
11. Strehlow K ^ Rotter S, Wassmann S, Adam O, Grohe C, Laufs K. Böhm, G Nickenig (July 2003). "Modulation of antioxidant enzyme expression and function by estrogen. Circ. Res 93 (2): 170-7. Doi: 10.1161/01.RES.0000082334.17947.11. PMID 12816884.
12. ^ Hwang J, Wang J, P Morazzoni, Hodis HN, A Sevani (April 2003). "The phytoestrogen equol increases nitric oxide availability by inhibiting the production superoxide: an antioxidant mechanism for mediation of LDL modified cells. Free Radic. Med Biol 34 (10): 1271-1282. PMID 12,726,915.
13. ^ DiSilvestro RA, Goodman J, Dy E, Lavalle G (February 2005). "Soy isoflavone supplementation elevates superoxide dismutase erythrocyte but not plasma ceruloplasmin in postmenopausal breast cancer survivors. Breast Cancer Res Treat 89. (3): 251-5. doi: 10.1007/s10549-004-2227-6. PMID 15754123.
14. Koubova ^ J, L Guarente (February 2003). "How the restriction heat? . Genes Dev 17. (3): 313-21. Doi: 10.1101/gad.1052903. PMID 12569120. Lay Summary – New York Times.
15. ^ Rothschild, Peter, et al. al (1988). "The absorption of oral enzymes and enzyme therapy of immune complexes and radical Exempt .. disease tariff Laboratories University Press, Honolulu, Hawaii.
16. S Nersesyan Knasmüller A, M ^ C Misik Gerner, W Mikulits, Ehrlich V, Hoelzl C, Szakmary A Wagner, KH (May 2008). "Using conventional and-omics based methods for health claims for antioxidants: a critical perspective. Br J Nutr. 99 E 1 Suppl: SS3-52. Doi: 10.1017/S0007114508965752. PMID 18503734.
17. Birkhäuser ^ Basel (September 2006). "Therapeutic potential of superoxide dismutase (SOD) for resolution of inflammation." Inflammation Research Journal: 359-363. DOI 10.1007/s00011-006-5195-y. ISSN 1023-3830.
18. ^ Medical dictionary [2]
19. Amyotrophic_lateral_sclerosis ^ # SOD1
20. Zidenberg Cherri-S ^, et al. (1983). "The superoxide dismutase does not affect levels of food .. tissue Am J Clin Nutr 37:5.

11 External links

• "Food Agrigenic Company.
• "SFRBM – Society for free radical biology and medicine.

12 See also

• Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, R. Cape, Sinclair DA (July 2004). "Calorie restriction promotes survival mammalian cells by inducing SIRT1 deacetylase. "Science 305 (5682): 390-2.doi: 10.1126/science.1099196. PMID 15205477.
• Picard M, Kurtev M, N Chung, Topark-Ngarm A Senawong T, Machado de Oliveira R, Leid M, McBurney MW, Guarente L (June 2004). "Sirt1 promotes fat mobilization in white adipocytes of the repression of PPAR-gamma. "Nature 429 (6993): 771-6.doi: 10.1038/nature02583. PMID 15175761.
• Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (September 2003). "Molecule activators of sirtuins extend Saccharomyces cerevisiae small life." Nature 425 (6954): 191-6.doi: 10.1038/nature01960. PMID 12939617.
• Wood JG, ROGINA B, Lavu S, Howitz K, Helfand M SL, Tatar, Sinclair D (August 2004). "Triggers Sirtuin mimic caloric restriction and delay aging in metazoans. Nature 430 (7000): 686-9. Doi: 10.1038/nature02789. PMID 15254550.
• Floh L (December 1988). "Superoxide dismutase for therapeutic use: clinical experience, the dead ends and hopes . Mol. Cell. Biochem. 84 (2): 123-31. PMID 3068519.
• Muth CM, Y Glenz, Klaus M, Radermacher P, Speit G, Leverve X (September 2004). "The influence of an effective oral SOD on cell damage associated with hyperbaric oxygen. Free Radic. Res 38 (9): 927-32. Doi: 10.1080/10715760412331273197. PMID 15621710.

About the Author

Robert Kavanaugh is an accomplished researcher whose primary focus over the past twenty years has been free radical biology and medicine.

ABC Primetime Special on Protandim

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